Genetic susceptibility to occupational exposures

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Genetic susceptibility to occupational exposures.

Because of their high prevalence in the general population, genetic variants that determine susceptibility to environmental exposures may contribute greatly to the development of occupational diseases in the setting of specific exposures occurring in the workplace. Studies investigating genetic susceptibilities in the workplace may: (1) provide mechanistic insight into the aetiology of disease,...

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Genetic screening and occupational and environmental exposures.

but policies based on freedom of choice divorced from an awareness of the broader social context have the potential to favour the wealthy, the highly educated, and the genetically healthy. Not everyone, for example, has the choice about where they are going to work—lack of skills, lack of mobility, living in an area of high unemployment, and so on may make it impossible for those who are reject...

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Different People, Different Outcomes: Assessing Genetic Susceptibility to Lead Exposures

lead toxicity manifests. A new study in fruit flies scrutinizes susceptibility on the genetic level and highlights genes that might help shape individual responses. “There are several problems in trying to find out variations and susceptibility to lead in human populations,” says study coauthor Robert Anholt, a professor of biological sciences at North Carolina State University. Uncontrolled ge...

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Ethnic differences in reactions to drugs and xenobiotics. Susceptibility to occupational and environmental exposures to chemicals.

I have presented some diverse case reports which illustrate several variations on the theme of this conference. A study of caffeine metabolites revealed two kinds of interethnic variation, one pertaining to the well-known acetylation polymorphism affecting the secondary metabolism of the parent drug; the other consisted of a difference in paraxanthine excretion which might indicate an ethnic di...

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Genetic Variability in Susceptibility to Occupational Respiratory Sensitization

Respiratory sensitization can be caused by a variety of substances at workplaces, and the health and economic burden linked to allergic respiratory diseases continues to increase. Although the main factors that affect the onset of the symptoms are the types and intensity of allergen exposure, there is a wide range of interindividual variation in susceptibility to occupational/environmental sens...

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ژورنال

عنوان ژورنال: Occupational and Environmental Medicine

سال: 2008

ISSN: 1351-0711

DOI: 10.1136/oem.2007.033977